ClinTrial Refer

Trial Acronym
Aeon

Registration Number
NCT05016661

Scientific Title
A Randomized, Multicenter, Dose-Blinded, Phase 2 Extension Study of ABP-450 (prabotulinumtoxinA) Purified Neurotoxin Complex for the Prevention of Migraine Headache

This Phase 2 Extension trial will evaluate the efficacy and safety of ABP-450 for migraine
prevention in adults who suffer from six or more migraine days per month. The study will
enroll approximately 666 patients across approximately 65 sites in the United States, Canada
and Australia from the Phase 2 trial. Study subjects will be divided evenly across a low dose
group and a high dose group. All patients will receive four treatment cycles of ABP-450
utilizing the Company's novel injection paradigm.

1. Patient can understand the ICF, provides signed ICF and patient privacy information (eg, Authorization for Use and Release of Health and Research Study Information) before initiating any study-specific procedure, and agrees to comply with protocol requirements.

    2. Patient was enrolled in Study ABP-20001 and successfully completed that study's treatment and procedures.

    3. A WOCBP must be willing and able to use a medically acceptable and effective method of birth control, as determined by the investigator, during the entire study (Appendix 13.3).

    4. A WOCBP (Appendix 13.3) must have a negative urine pregnancy test at Visit 1.

    5. Patient can read, understand, and complete the eDiary.

    6. Patient is willing and able to adhere to the study assessments, visit schedules, and prohibitions, as described in this protocol.

1. Did not meet eligibility criteria for Study ABP-20001 and was improperly enrolled or randomized in that study.

    2. Failure to successfully complete the Study ABP-20001, including the following:
   1. use of prohibited medications
   2. delay of >4 weeks in receiving second Study ABP-20001 investigational study drug      injection
   3. completing fewer than 75% of eDiary entries during the 28-week treatment and      follow-up period
   4. 7 or more consecutive missed days of eDiary entries Note: if the investigator      determines that any of the above 4 failures occurred due to extenuating      circumstances, patients may be allowed to enroll in Study ABP-20002 if the      investigator expects the problem will not recur.
 Medical Conditions:

    3. History of migraine accompanied by diplopia or decreased level of consciousness, or retinal migraine.

    4. Current diagnosis of chronic tension-type headache, new persistent daily headache, trigeminal autonomic cephalgia (eg, cluster headache), or cranial neuropathy.

    5. Confounding and clinically significant pain syndromes (eg, fibromyalgia, chronic low back pain, complex regional pain syndromes) as evaluated by the investigator.

    6. Diagnosis of myasthenia gravis, Lambert-Eaton syndrome, amyotrophic lateral sclerosis, or any other significant neuromuscular disease that might interfere with the study.

    7. Psychiatric conditions that are uncontrolled and/or untreated as evaluated by the investigator.

    8. Lifetime history of psychosis, mania, or dementia.

    9. History of addiction, including alcohol or drug abuse since initiating ABP-20001 study treatment.

   10. Any infection or clinically significant skin problem in any of the injection sites.

   11. Any medical condition (including but not limited to viral or other active infections) that, in the opinion of the investigator, classifies the patient as unsuitable for participation in the study or patients who do not seem to be in good general health at the time of signing the informed consent, and prior to any investigational study drug administration.
 Note: Patients will not routinely be tested for COVID-19 during the study. Patients presenting with fever or who are symptomatic for COVID-19 will be required to be tested and treated through their general practitioner.
 Other Diagnostic Assessments:

   12. Significant risk of self-harm based on clinical interview and responses on the C-SSRS, or of harm to others in the opinion of the investigator; patients must be excluded if they report suicidal ideation with intent, with or without a plan (ie, Type 4 or 5 on the C-SSRS) in the time since enrolling in Study ABP-20001.
 Prior/Concomitant Medications and Treatments

   13. Injection with anesthesia or steroids in the targeted muscles since initiating ABP-20001 study treatment.

   14. Use of opioids or barbiturates >2 days per month since initiating ABP-20001 study treatment.

   15. Use of CBD or other types of cannabinoids since initiating ABP-20001 study treatment.

   16. Use of botulinum toxin at or above the shoulders other than ABP-20001 study treatment since initiating ABP-20001 study treatment.

   17. Any CGRP inhibitor treatment (eg, erenumab [Aimovig®], eptinezumab [Vyepti™], fremanezumab [Ajovy®], or galcanezumab [Emgality®], rimegepant sulfate [Nurtec™], ubrogepant [Ubrelvy™] within or outside of a clinical study) since initiating ABP-20001 study treatment.

   18. Use of small molecule migraine drugs (eg, beta blockers, anticonvulsants, antidepressants, calcium channel blockers) since initiating ABP-20001 study treatment.

   19. Use of devices for the treatment of migraine (ie, non-invasive neuromodulation therapies including but not limited to non-invasive nerve stimulation [gammaCore], transcranial magnetic stimulation [cephaly], external trigeminal nerve stimulation, transcutaneous electrical nerve stimulation, and peripheral neuroelectrical stimulation) since initiating ABP-20001 study treatment.

   20. Any other treatments or therapies (eg, acupuncture in head and neck region, cranial traction, nociceptive trigeminal inhibition, occipital nerve block treatments, and dental splints for headache) to the head, neck, or shoulder regions since initiating ABP-20001 study treatment that, in the opinion of the investigator, would interfere with the investigational study drug.

   21. History of inadequate response to 3 classes of medications (which have different mechanisms of action) prescribed for the prevention of migraine, excluding CGRP therapies.

   22. History of hypersensitivity to human serum albumin, sucrose, or botulinum toxin type A.

   23. Participation in another interventional study since initiating ABP-20001 study treatment. Other

AEON Biopharma, Inc.

Website URL

Link Name

Link URL

ANZCTR

http://www.anzctr.org.au/TrialSearch.aspx?searchTxt=NCT05016661

Clinicaltrials.gov

https://clinicaltrials.gov/ct2/show/NCT05016661

Secondary IDs
ABP-20002

Study Type
Interventional

Intervention Code
Treatment - Drugs

Phase
Phase 2

Minimum Age
18

Maximum Age
100

Date Registered
12/04/2023

Date Closed
N/A

Status
Closed

Enrolment Type
By Self-Referral,By Specialist and/or Surgeon Referral,Primary Care or GP Referral

Mutation Status and Biomarker
Any or not stated

Is it a Cohort Trial?
No

Is this a Tele-Trial?
No

Can healthy volunteer participate?
No

Discipline

Health Condition

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